| Odds via Tonybet | |
| Inter Miami CF vs Nashville SC | Friday, October 24, 2025, 8 PM EDT |
| Inter Miami CF odds | -193 |
| Nashville SC odds | +380 |
| Draw | +370 |
| Both teams to score | Yes -223, No +154 |
Inter Miami CF vs Nashville SC Preview and Team News
Inter Miami CF Team News
Inter Miami ended the 2025 MLS regular season on a hot streak with three straight wins, including a 5-2 drubbing of Nashville at Geodis Park on October 18, so they should have tons of confidence for this clash.
The Herons are a different, more dangerous team when Lionel Messi is clicking, and the Argentinian superstar has been on a tear of late with five goals and five assists during their winning run.
Having notched 29 goals and 16 assists across 28 regular-season appearances, Messi is on the heels of securing a second straight MLS MVP award, something no player in the league has ever done.
Back and ready. Full steam ahead 🚂 pic.twitter.com/DmBFyKoAhD
— Inter Miami CF (@InterMiamiCF) October 22, 2025
His dominance aside, Inter Miami have looked almost unstoppable at home, with nine wins in their last 11 fixtures (W9, D1, L1), with the lone defeat being a 5-3 loss to the Chicago Fire on September 30.
That loss was also the last time the club suffered a defeat of any kind, as they scored 13 goals over a three-game stretch to close out the regular season on a heater. Their impressive form should be enough to back up their status as favourites ahead of this Round of 16 opener.
Inter Miami CF predicted lineup vs Nashville SC (4-2-3-1): Ríos Novo; Weigandt, Luján, Falcón, Jordi Alba; Busquets, De Paul; Allende, Messi, Rodríguez; Suárez.
Nashville SC Team News
There’s no doubt that Nashville SC have the offensive power to at least unsettle Inter Miami. As good as the Herons are in attack, they also tend to leave quite a few gaps in defense. It wouldn’t be a surprise if the visitors found a way to score at least once here, as both sides have found the net in each of their previous three head-to-head meetings at Chase Field across all competitions.
However, scoring a goal is one thing, and pulling off an upset against the hottest team in the league is another. Nashville SC aren’t known for being a top performer on the road, having ended the 2025 regular season on a seven-game winless skid away from Geodis Park (D1, L6). They scored at least once in six of those seven matches, though.
All the data points to Nashville being clear underdogs. Even if they’re at full strength with key players Walker Zimmerman and Hany Mukhtar, it’s hard to imagine a scenario where they can slow down Miami’s potent attacking line, especially given their recent road woes.
Nashville SC predicted lineup vs Inter Miami CF (4-4-2): Willis; Najar, Maher, Zimmerman, Lovitz; Muyl, Brugman, Tagseth, Boyd; Surridge, Mukhtar.
Inter Miami CF vs Nashville SC Main Match Info
- Date and Kickoff Time: Friday, October 24, 2025, 8 PM EDT
- Stadium: Chase Field
- Location: Miami, FL, USA
- Last match: Nashville SC 2:5 Inter Miami CF (October 18, 2025, MLS)
Inter Miami CF vs Nashville SC Prediction, Odds
- Pick: Inter Miami win and both teams to score – yes
- Odds: +142 (Tonybet)
- Correct score prediction: Inter Miami CF 3-1 Nashville SC
Inter Miami were a dominant team at home during the regular season, finishing with a W11, D3, L3 record and winning four of their last five. With that in mind, it’s easy to believe they’ll come out firing in this match, especially with the support of their fans at Chase Field. Given the experience the Herons have on their roster, they shouldn’t feel pressured by the atmosphere of the MLS Playoffs.
These two sides met in the final week of the regular season. Even though Nashville held a 2-1 lead at halftime, Inter Miami bounced back to secure a comfortable 5-2 win, fueled by a Lionel Messi hat-trick. The Herons have the better squad on an individual level, and having difference-making talent can go a long way in the postseason. Expect them to use that to their advantage to win in the first leg of this tie.
Inter Miami CF vs Nashville SC Betting Tip
- Pick: Inter Miami to lead at HT
- Odds: -106 (Tonybet)
No team in the Eastern Conference led more games at halftime when playing at home than Inter Miami, who did so in 11 of their 17 matches – tied for first with Philadelphia Union. Leading at the break was a synonym for success for the Herons, as they went on to win 10 of those 11 fixtures.
Known for their strong starts at home and boosted by their fans at Chase Field, the hosts have everything they need to get a good result here. Nashville SC will likely aim to play more conservatively after conceding five goals to Inter Miami last week, and their overall road woes don’t help their cause, either. All things considered, it wouldn’t be surprising if Javier Mascherano’s men go into halftime with the lead.
Inter Miami CF vs Nashville SC: Where to Watch (Canada)
- MLS Season Pass
- Amazon Prime Video
- RDS
- RDS App
- TSN2
- EA Sports FC
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