| Odds via Tonybet | |
| Liverpool vs Southampton | Tuesday, September 23, 2025, 03:00 PM EDT |
| Liverpool odds | -626 |
| Southampton odds | +1300 |
| Draw | +680 |
| Both teams to score | Yes -110, No -121 |
Liverpool vs Southampton Preview and Team News
Liverpool Team News
Despite a challenging start to the season, Liverpool have proved that they remain one of the top favourites to compete for every trophy. They’ve scored decisive goals after the 80th minute in five of their seven games, demonstrating powerful mentality and resilience.
The last round was an exception, as Arne Slot’s side grabbed a comfortable victory over Everton. Although the Toffees pulled one back, the Reds stayed in control and eventually sealed a win.
Liverpool have won the EFL Cup twice in the last four years. Last season, they had a great opportunity to improve their record, but lost 1-2 to Newcastle in the final.
Liverpool predicted lineup vs Southampton (4-2-3-1): Mamardashvili; Bradley, Leoni, Gomez, Robertson; Nyoni, Endo; Chiesa, Jones, Gakpo; Isak.
Southampton Team News
Southampton would happily erase last season from their memory. They suffered 30 defeats in 38 matches, picked up 12 points, and finished with a goal difference of 26-86, which saw them relegated to the Championship.
The Saints clearly need a boost to return to the English top tier. However, confidence is still lacking as they’re on a five-game winless streak and sit in 19th place in the table.
The EFL Cup has at least provided a spark of hope for Will Still’s men. They began their journey with a hard-fought 1-0 victory over Northampton and continued with a surprisingly convincing 3-0 rout of Norwich. Still, a clash with much stronger opponents leaves their chances of advancing to the next round looking slim.
Southampton predicted lineup vs Liverpool (4-2-3-1): Bazunu; Roerslev, Stephens, Harwood-Bellis, Manning; Charles, Downes; Fellows, Azaz, Fraser; Archer.
Liverpool vs Southampton Main Match Info
- Date and Kickoff Time: Tuesday, September 23, 2025, 03:00 PM EDT
- Stadium: Anfield
- Location: Liverpool, England
- Last match: Liverpool 3-1 Southampton (March 8, Premier League)
Liverpool vs Southampton Prediction, Odds
- Pick: Southampton (+2.5) Handicap
- Odds: -143 (Tonybet)
- Correct score prediction: Liverpool 3-1 Southampton
Liverpool approach this clash as heavy favourites, but a congested schedule will force them to prioritize important matches. Arne Slot’s men face tough trips to Crystal Palace and Galatasaray, followed by a showdown with Chelsea.
As a result, the hosts are expected to turn to a massive revamp of the starting lineup. A major rotation might be inevitable. Also, looking back at last season’s meetings, Southampton lost by scores of 2-3, 1-2, and 1-3.
Across the last 10 encounters, Liverpool have managed to beat the Saints with two goals or more twice. We expect the visitors to show greater motivation and resilience this time around.
Liverpool vs Southampton Betting Tip
- Pick: Both Teams to Score
- Odds: -110 (Tonybet)
Meetings between Liverpool and Southampton have always been filled with fire, brilliance, and a ton of emotion. In the last eight head-to-heads, there have been at least three goals, with both teams finding the net in six of them.
We’re expecting goals from the hosts, but the visitors aren’t too modest either. Southampton have only left the pitch without scoring in one of their eight matches so far this season.
Without key centre-backs, Liverpool’s defence could allow some errors, offering the Saints opportunities in attack. All signs point to a lively affair at Anfield.
Liverpool vs Southampton: Where to Watch (Canada)
- DAZN
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