Manchester United vs Chelsea Prediction, Preview, Team News and Lineups 20.09.2025
Calendar icon Published 18 Sep 15:05

Manchester United vs Chelsea Prediction, Preview, Team News and Lineups 20.09.2025

Juan Pablo Aravena Juan Pablo Aravena
Odds via Tonybet
Manchester United vs ChelseaSaturday, September 20, 2025, 12:30 PM EDT
Manchester United odds +175
Chelsea odds +145
Draw+270
Both teams to scoreYes -193, No +154 

Manchester United vs Chelsea Preview and Team News

Manchester United Team News

Manchester United continue to underperform against top clubs, having suffered a disappointing 3-0 defeat to City in their most recent outing. Facing a third “Big Six” opponent within the first five fixtures of the season is far from ideal for a struggling side. 

Still, the Old Trafford outfit continue to show the same deficiencies that made them finish in the bottom half of the 2024-25 standings. They enter this matchup against Chelsea in 14th place after four encounters (W1, D1, L2).

The lack of efficiency in the final third has been the biggest issue for Manchester United. The Red Devils have taken 94 shots across their last four Premier League matches at home, but have netted just four goals. After investing more than $250 million to bolster their attack in the summer transfer window, neither Benjamin Sesko nor Matheus Cunha has found the net, leaving the team with just four goals across four EPL contests.

Cunha is expected to be sidelined for this clash due to a hamstring injury, while Diogo Dalot, Lisandro Martínez, and Mason Mount are also out. Perhaps the most significant change from the loss to Manchester City could be the debut of their latest signing, Senne Lammens, who is tipped to replace Altay Bayindir between the posts. If selected, it would mark the Belgian’s first appearance for United

Manchester United predicted lineup vs Chelsea (3-4-3): Lammens; Yoro, De Ligt, Shaw; Mazraoui, Casemiro, Bruno Fernandes, Dorgu; Diallo, Sesko, Mbeumo.

Chelsea Team News

Chelsea have delivered back-to-back underwhelming performances over the last seven days. The team need to turn things around before the pressure starts mounting on manager Enzo Maresca. 

The Blues were held to a 2-2 draw by Brentford despite dominating in their previous Premier League outings. They also suffered a disappointing 3-1 defeat against Bayern Munich in their UEFA Champions League opener on Wednesday.

The Stamford Bridge side looked outmatched at times against Bayern, particularly on the defensive end, and it’s clear that the lack of an established, star-level centre-back is hurting them. 

Chelsea have recorded just one clean sheet in their last four competitive matches, underlining the urgent need for defensive improvements if they want to get a positive result out of this visit to Old Trafford.

Maresca’s squad remains depleted, with the likes of Liam Delap, Levi Colwill, Romeo Lavia, and Benoit Badiashile all sidelined with injuries. However, the Blues have recently welcomed Cole Palmer back in the starting lineup, and Reece James could return to the side as well. Even after the 3-1 loss to Bayern, Chelsea aren’t expected to make massive changes to the XI they’ve been fielding lately.

Chelsea predicted lineup vs Manchester United (4-2-3-1): Sánchez; James, Tosin, Chalobah, Cucurella; Fernández, Caicedo; Gittens, Palmer, Pedro Neto; João Pedro. 

Manchester United vs Chelsea Main Match Info

Manchester United vs Chelsea Prediction, Odds

Manchester United need to find a way to get a positive result and get back to winning ways sooner rather than later, as the pressure is beginning to mount on manager Ruben Amorim. 

The Portuguese tactician could be on his way out of Old Trafford if results don’t improve soon, but getting a win over Chelsea might be easier said than done given ManU’s struggles against top sides in recent years.

Even though the Red Devils are undefeated in their last 12 league home meetings against Chelsea (W5, D7), the Blues are desperate to bounce back after losing to Bayern Munich and drawing with Brentford last weekend. They should take advantage of United’s lack of confidence and defensive woes to secure a victory here, though all signs point to this being a tight game.

Manchester United vs Chelsea Betting Tip

United were unable to find the back of the net against Arsenal and City despite having enough chances to do so. It’s also worth noting that Chelsea are a few steps below the two aforementioned teams in terms of defensive prowess, as evidenced by their 3-1 loss to Bayern Munich in the Champions League earlier this week. 

That said, don’t rule out Manchester United from scoring at least once here.

However, they’re also highly unlikely to keep a clean sheet. They’ve yet to do so in five competitive matches this season and have conceded at least two goals in each of their last three.

Chelsea should be able to find the back of the net here, as they’ve scored nine times across their previous three EPL outings. Thus, a game with over 2.5 goals and both sides scoring looks like the most probable outcome. That scenario has also played out in three of their last five league head-to-heads.

Manchester United vs Chelsea: Where to Watch (Canada) 

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